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Computational analysis of phenotypic space in heterologous polyketide biosynthesis--applications to Escherichia coli, Bacillus subtilis, and Saccharomyces cerevisiae.

J Theor Biol 2010,Jan,21;262(2):197-207; (PMID: 19833139)
[...]In this work, we applied flux balance analysis on genome-scale models to simulate cellular metabolism and 6-deoxyerythronolide B (the cyclized polyketide precursor to erythromycin) production in three common heterologous hosts (E. coli, Bacillus subtilis, and S. cerevisiae) under a variety of carbon-source and medium compositions. We then undertook minimization of [...]

Study of gel-forming properties of sucrose esters for thermosensitive drug delivery systems.

Int J Pharm 2010,Jan,04;383(1-2):132-7; (PMID: 19748563)
Sucrose esters (SEs) are non-toxic, biodegradable, non-ionic surfactants. They have a wide range of hydrophilic-lipophilic balance values (1-16) and are usually applied as surfactants, or as solubility or penetration enhancers. The aims of this work were to study the gelling behaviour of SEs and the effects of this property on drug release.[...]

Antimicrobial susceptibility and macrolide resistance genes in Enterococcus faecium with reduced susceptibility to quinupristin-dalfopristin: level of quinupristin-dalfopristin resistance is not dependent on erm(B) attenuator region sequence.

Diagn Microbiol Infect Dis 2010,Jan,01;66(1):73-7; (PMID: 18653303)
[...]) MIC > or =1 microg/mL. As expected, higher levels of resistance were detected for macrolide antibiotics (94% erythromycin, 100% azithromycin, 100% josamycin). High-level resistance to gentamicin and streptomycin was detected in 18.9% and 66.2% of isolates, respectively, in our series of enterococci.[...]

Acute sensitivity of activated sludge bacteria to erythromycin.

J Hazard Mater 2009,Dec,30;172(2-3):685-92; (PMID: 19674840)
[...]In many cases, biological wastewater treatment plants are the final opportunity in the water cycle to trap these substances. The sensitivity of activated sludge bacteria to erythromycin, a macrolide widely used in human medicine was investigated in batch toxicity tests using a concentration range of 1-300 mg L(-1).[...]

Mechanisms of resistance for Streptococcus pyogenes in northern Utah.

Clin Lab Sci 2009,Dec,21;22(1):39-44; (PMID: 19354028)
[...]OBJECTIVE: The purpose of this study was to (1) determine the rates of penicillin and erythromycin resistance among Streptococcus pyogenes isolates in northern Utah, and (2) determine the genotype of the [...]

The safety of macrolides during lactation.

Breastfeed Med 2009,Dec,01;4(4):197-200; (PMID: 19366316)
[...]RESULTS: Fifty-five infants exposed to macrolide antibiotics were compared to a control cohort of 36 infants exposed to amoxicillin via lactation. The infants in the macrolide group were all exposed to erythromycin and the newer macrolides: azithromycin, clarithromycin, and roxithromycin. The rate of adverse reactions the infant experienced while being exposed to both antibiotics was comparable.[...]

Antibiotic resistance genes in the vaginal microbiota of primates not normally exposed to antibiotics.

Microb Drug Resist 2009,Dec,01;15(4):309-15; (PMID: 19857138)
[...] canal, were tested for the presence of two types of antibiotic resistance genes: tetracycline resistance (tet) genes and erythromycin resistance (erm) genes. These genes are frequently found in human isolates of the two types of bacteria that were a substantial part of the normal microbiota of primates (Firmicutes and Bacteroidetes).[...]

The impact of the pneumococcal conjugate vaccine on antimicrobial resistance in the United States since 1996: evidence for a significant rebound by 2007 in many classes of antibiotics.

Microb Drug Resist 2009,Dec,01;15(4):261-8; (PMID: 19857132)
[...]Adjusted prevalence rates in a multivariate model declined in the period 2001-2004 for penicillin, erythromycin, amoxicillin/clavulanate, trimethoprim/sulfamethoxazole, tetracycline, ceftriaxone, and multidrug.[...]

Comparative activity of oritavancin against meticillin-resistant Staphylococcus aureus (MRSA) bloodstream isolates from Geneva University Hospital.

Int J Antimicrob Agents 2009,Dec,01;34(6):540-3; (PMID: 19744838)
[...] MIC > or = 4 microg/mL) for all isolates; 89% and 100% of the tested isolates were also resistant to erythromycin and ciprofloxacin, respectively. For 53 MRSA isolates for which vancomycin MICs were in the susceptible range (0.5-2.0 microg/mL), the [...]

Time-kill kinetics of oritavancin and comparator agents against Streptococcus pyogenes.

Int J Antimicrob Agents 2009,Dec,01;34(6):550-4; (PMID: 19818587)
[...] concentrations as well as time-kill assays. Ten clinical isolates of S. pyogenes, three of which were resistant to erythromycin, as well as one reference S. pyogenes strain were tested. In the time-kill assays, [...]
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