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Results for "TROY": Medline ( 4,281 ) | Full Text ( 411 ) | Grants ( 423 )

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Drug ratio-dependent antagonism: a new category of multidrug resistance and strategies for its circumvention.

Methods Mol Biol 2010,Jan,01;596:291-323; (PMID: 19949929)
A newly identified form of multidrug resistance (MDR) in tumor cells is presented, pertaining to the commonly encountered resistance of cancer cells to anticancer drug combinations at discrete drug:drug ratios. In vitro studies have revealed that whether anticancer drug combinations interact synergistically or antagonistically can depend on the ratio of the combined agents.[...]

Harnessing color vision for visual oximetry in central cyanosis.

Med Hypotheses 2010,Jan,01;74(1):87-91; (PMID: 19699589)
Central cyanosis refers to a bluish discoloration of the skin, lips, tongue, nails, and mucous membranes, and is due to poor arterial oxygenation.[...]

Composition, distribution, and potential toxicity of organochlorine mixtures in bed sediments of streams.

Sci Total Environ 2010,Jan,01;408(3):594-606; (PMID: 19906406)
Mixtures of organochlorine compounds have the potential for additive or interactive toxicity to organisms exposed in the stream. This study uses a variety of methods to identify mixtures and a modified concentration-addition approach to estimate their potential toxicity at 845 stream sites across the United States sampled between 1992 and 2001 for organochlorine pesticides and polychlorinated biphenyls (PCBs) in bed sediment.[...]

Serum anti-GAGA4 IgM antibodies differentiate relapsing remitting and secondary progressive multiple sclerosis from primary progressive multiple sclerosis and other neurological diseases.

J Neuroimmunol 2009,Dec,10;217(1-2):95-101; (PMID: 19879655)
The serum level of IgM antibodies against Glc(alpha1,4)Glc(alpha) (GAGA4) is higher in relapsing remitting multiple sclerosis (RRMS) compared to other neurological disease (OND) patients and healthy controls (HC). Detecting the level of anti-GAGA4 antibody by [...]

Mechanism of fibril formation by a 39-residue peptide (PAPf39) from human prostatic acidic phosphatase.

Biochemistry 2009,Dec,08;48(48):11582-91; (PMID: 19902966)
PAPf39 is a 39-residue peptide fragment from the sequence of human prostatic acidic phosphatase. This peptide was shown to form amyloid-like fibrils, which have been implicated in facilitating semen-mediated HIV transmission. Thus understanding molecular details of PAPf39 peptide fibril formation may aid in elucidating the mechanism of how PAPf39 fibrils are involved in HIV etiology.[...]

Cardiac fibroblast: the renaissance cell.

Circ Res 2009,Dec,04;105(12):1164-76; (PMID: 19959782)
The permanent cellular constituents of the heart include cardiac fibroblasts, myocytes, endothelial cells, and vascular smooth muscle cells. Previous studies have demonstrated that there are undulating changes in cardiac cell populations during [...]

The absorption efficiency and respiration rate of the Florida lancelet, Branchiostoma floridae.

Comp Biochem Physiol A Mol Integr Physiol 2009,Dec,01;154(4):570-4; (PMID: 19758577)
The present study investigates some aspects of the digestive biology and physiological energetics of the Florida lancelet, Branchiostoma floridae. Florida lancelets are able to remove 47.2-56.9% of the energy from a diet of mixed algae.[...]

Autoantibodies against phosphatidylserine, prothrombin and phosphatidylserine-prothrombin complex: identical or distinct diagnostic tools for antiphospholipid syndrome?

Clin Chim Acta 2009,Dec,01;410(1-2):19-24; (PMID: 19751711)
BACKGROUND: To clarify the association and diagnostic utility of measuring antiphosphatidyl serine (aPS), antiprothrombin (aPT) and the antiphosphatidyl serine/prothrombin complex (aPS/PT) antibodies in patients with antiphospholipid syndrome (APS) and recurrent pregnancy loss (RPL). METHOD: We measured IgG and IgM anti-aPS/PT (2 different kits) as well as the aPS and aPT autoantibodies by [...]

Emergent US adenovirus 3 strains associated with an epidemic and serious disease.

J Clin Virol 2009,Dec,01;46(4):331-6; (PMID: 19854101)
BACKGROUND: Adenovirus type 3 (HAdV3) is one of the most prevalent serotypes detected globally. Variants of HAdV3 have been associated with outbreaks of severe disease. OBJECTIVES: To better understand genetic diversity of circulating HAdV3s and examine risk factors for severe disease.[...]

FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain.

Development 2009,Dec,01;136(23):4021-31; (PMID: 19906869)
Neuronal specification occurs at the periventricular surface of the embryonic central nervous system. During early postnatal periods, radial glial cells in various ventricular zones of the brain differentiate into ependymal cells and astrocytes. However, mechanisms that drive this time- and cell-specific differentiation remain largely unknown.[...]
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