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Clin Toxicol (Phila) 2009,Nov,01;47(9):889-93; (PMID: 19821638)
[...] poisonings occurred in Oslo in 2008 among users of illicit drugs, caused by fake Rohypnol pills. The clinical features, diagnostic process, and handling of the epidemic are presented. METHODS: Suspected cases of [...]
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J Anal Toxicol 2009,Oct,01;33(8):491-501; (PMID: 19874658)
We investigated the excretion profiles of flunitrazepam metabolites in urine after a single dose. Sixteen volunteers received either 0.5 or 2.0 mg [...]
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J Pharmacol Sci 2009,Sep,01;111(1):44-52; (PMID: 19721330)
[...] antagonized only the increase in sleep latency induced by MK-801, whereas, risperidone, quetiapine, and flunitrazepam had no effect in the changes of sleep-wake pattern induced by MK-801. Olanzapine increased delta activity and decreased beta activity during [...]
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Ann Pharm Fr 2009,Sep,01;67(5):353-9; (PMID: 19695371)
[...] as defined by a decrease in the partial pressure of oxygen in arterial blood (PaO(2)). In contrast, the combination of buprenorphine with flunitrazepam results in a decrease in PaO(2). This harmful interaction does not exist with other benzodiazepines[...]
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Prog Neuropsychopharmacol Biol Psychiatry 2009,Aug,31;33(6):933-8; (PMID: 19409441)
[...], and if changes were similar in both genders. METHODS: This was a double-blind, cross-over design study of acute oral flunitrazepam (1.2 mg) and placebo in young, healthy, male and female (n=21) volunteers. Blood samples were collected 3 h after ingestion (after peak-plasma concentration of [...]
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J Chromatogr B Analyt Technol Biomed Life Sci 2009,Aug,01;877(23):2275-83; (PMID: 19110476)
A LC-APPI-MS method was developed and validated for the detection of alprazolam, flunitrazepam and their major metabolites in haemolysed blood. Samples were diluted with water (2:1, v:v) and extracted with a hydrophobic-lipophilic balanced copolymer.[...]
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Biochem Pharmacol 2009,Jul,01;78(1):96-103; (PMID: 19447228)
[...] enteric contents and characterized the role of enterobacterial nitroreductase in the reductive pathway. Nitroreduction of flunitrazepam (FZ) was studied in the microsomal membrane fractions of rat liver, jejunum[...]
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Int J Geriatr Psychiatry 2009,Jul,01;24(7):731-8; (PMID: 19127524)
[...]RESULTS: > or =1 BZDs/BZDRDs and > or =2 BZDs/BZDRDs were used by 25% and 5% of the study population, respectively. The most commonly used BZDs/BZDRDs were zopiclone, zolpidem, oxazepam, flunitrazepam, and diazepam. The probability of use BZDs/BZDRDs increased with age, female gender, living in an urban area, use of many other drugs, and concomitant use of other psychotropics, particularly antidepressants.[...]
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Psychopharmacology (Berl) 2009,Jul,01;204(4):667-77; (PMID: 19274455)
[...]OBJECTIVES: The current study evaluated changes in sensitivity to positive GABA(A) modulators during chronic treatment with the benzodiazepine flunitrazepam to determine whether cross tolerance and cross dependence varied as a function of site of action.[...]
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Encephale 2009,Jun,01;35(3):220-5; (PMID: 19540407)
[...] were taking 70 to 300 mg per day, two thirds having experimented with a fixed dose of 100mg. Benzodiazepines, especially diazepam and flunitrazepam, were studied versus placebo. Thus, 10 to 20mg of diazepam gave rise to [...]
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