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J Cell Sci 2010,Aug,15;123(Pt 16):2717-24; (PMID: 20663921)
[...]LA-related protein 1 (LARP-1) belongs to an RNA-binding protein family containing a LA motif. Here, we identify LARP-1 as a regulator of sex determination. In C. elegans hermaphrodites, a complex regulatory network regulates the switch from sperm to oocyte production.[...]In C. elegans hermaphrodites, a complex regulatory network regulates the switch from sperm to oocyte production. We find that simultaneous depletion of larp-1 and the Nanos homologue nos-3 results in germline masculinization. This phenotype is accompanied by a strong reduction of the levels of TRA-1, a GLI-family transcription factor that promotes [...]
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RNA 2010,Aug,01;16(8):1488-99; (PMID: 20573744)
[...]Here, we have analyzed the cellular interactions and function of LARP4B, a thus far uncharacterized member of the LARP family. We show that LARP4B is a cytosolic protein that accumulates upon arsenite treatment in cellular stress[...]
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Biochim Biophys Acta 2010,May,01;1799(5-6):365-78; (PMID: 20138158) [FULL TEXT AVAILABLE]
[...]-RNA crystal structures as well as biochemical studies reveal insight into their unique two-motif domain architecture and how the LAM recognizes UUU-3'OH while the RRM binds other parts of a pre-tRNA. Recent studies of members of distinct families of conserved La-related proteins (LARPs) indicate that some of these harbor activity related to genuine La proteins, suggesting that their UUU-3'OH binding mode has been appropriated for the assembly and regulation of a specific snRNP (e.g., 7SK snRNP assembly by hLARP7/PIP7S).[...] proteins, suggesting that their UUU-3'OH binding mode has been appropriated for the assembly and regulation of a specific snRNP (e.g., 7SK snRNP assembly by hLARP7/PIP7S). Analyses of other LARP family members suggest more diverged RNA binding modes and specialization for cytoplasmic mRNA-related functions. Thus it appears that while genuine [...]
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J Neurophysiol 2009,Nov,01;102(5):2781-9; (PMID: 19710380)
[...] pair (RALP), and to a maximal activation of the left anterior/right posterior semicircular canal pair (LARP)]. Our sample of neurons recorded in the left pretectum had two preferred axes of rotation: first, rotation around the yaw axis and second, rotation around the RALP axis.[...]
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Dev Biol 2009,Oct,01;334(1):186-97; (PMID: 19631203)
[...] becomes clearer, we searched for genes that might specify such control in Drosophila. A maternal-effect lethal screen identified mutants in the Drosophila gene for Larp (La-related protein) which displayed maternal-effect lethality and male sterility. A role for La protein has already been implicated in [...]
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Pediatr Surg Int 2009,Jul,01;25(7):601-5; (PMID: 19517124)
PURPOSE: To describe a laparoscopy-assisted retroperitoneal pyeloplasty (LARP) and results of initial experience. METHODS: Port placement used by Farhat in retroperitoneal-assisted laparoscopic pyeloplasty was modified for better cosmetic results.[...]
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RNA 2009,May,01;15(5):750-64; (PMID: 19299548) [FULL TEXT AVAILABLE]
[...]A complete evolutionary and structural analysis of these proteins resulted in their classification into five families: the genuine La homologs and four LARP families. Unexpectedly, in each family a conserved domain representing either a classical RRM or an RRM-like motif immediately follows the LAM of most proteins.[...]
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RNA Biol 2009,Apr,01;6(2):122-8; (PMID: 19246988)
[...]It is stabilized by mono-methylation of its 5'-triphosphate group and binding of a specific La-Related protein, LARP7 at its 3' end. As the likely best characterized example, 7SK RNA is a paradigm for non-coding RNAs regulating [...]
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Biomol NMR Assign 2008,Dec,01;2(2):107-9; (PMID: 19636881)
[...](1)H, (15)N and (13)C chemical shift assignments are presented for the N-terminal region of human La protein, in the apo and 5'-UUUU RNA-bound state. Secondary structure analysis shows conformational changes in the interdomain linker upon complex formation.[...]
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J Virol 2008,Dec,01;82(23):11927-38; (PMID: 18829760) [FULL TEXT AVAILABLE]
Human La protein has been implicated in facilitating internal ribosome entry site (IRES)-mediated translation of hepatitis C virus[...]
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