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Nat Cell Biol 2009,Nov,01;11(11):1332-9; (PMID: 19855387)
[...]Moreover, IFT20 was required for the inducible assembly of a complex with other IFT components (IFT57 and IFT88) and the TCR. The results identify IFT20 as a new regulator of immune synapse assembly in T cells and provide the first evidence to implicate IFT in membrane [...]
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Vision Res 2009,Feb,01;49(4):479-89; (PMID: 19136023) [FULL TEXT AVAILABLE]
[...] particle is a multi-subunit complex and mutations in many individual components causes photoreceptor defects. In zebrafish, mutations in the ift57, ift88, and ift172 genes result in retinal degeneration by 5 days post fertilization[...]
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FEBS J 2008,Sep,01;275(17):4271-9; (PMID: 18637945)
[...]In the present review, we present evidence that Htt-interacting protein 1 (HIP-1), an endocytic protein, together with its interacting partner HIPPI, regulates apoptosis and gene expression, both processes being implicated in HD. Further studies are necessary to establish whether the HIPPI-HIP-1 complex or other interacting partners of HIPPI regulate [...]
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J Cell Sci 2008,Jun,01;121(Pt 11):1907-15; (PMID: 18492793)
[...]To determine whether photoreceptor outer segment formation depends equally on individual IFT proteins, we compared the retinal phenotypes of IFT57 and IFT88 mutant zebrafish. IFT88 mutants failed to form outer segments, whereas IFT57 mutants formed short outer segments with reduced amounts of opsin.[...]
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Apoptosis 2008,Mar,01;13(3):437-47; (PMID: 18188704)
[...]The HIPPI (HIP-1 protein interactor) protein is a multifunctional protein that is involved in the regulation of apoptosis. The interaction partners of HIPPI include HIP-1 (Huntingtin-interacting protein-1), Apoptin, Homer1c, Rybp/DEDAF, and [...]
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J Mol Biol 2008,Feb,01;375(5):1197-205; (PMID: 18155047)
[...]The release of the huntingtin protein permits HIP1 protein interactor (HIPPI) to bind to its recognition site on HIP1 to form a HIPPI/HIP1 complex that recruits procaspase-8 to begin the process of apoptosis[...]
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Annu Rev Pharmacol Toxicol 2008,Jan,01;48:143-69; (PMID: 17848136)
[...]cell death impulses. Apoptin targets include DEDAF, Nur77, Nmi, Hippi, and the potential drug target APC1. Apoptin-transgenic mice and animal tumor models have revealed apoptin as a safe and efficient antitumor agent, resulting in significant tumor regression.[...]
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Proc Natl Acad Sci U S A 2007,Dec,11;104(50):19843-8; (PMID: 18056639) [FULL TEXT AVAILABLE]
[...] showed that ciliary axonemal structures were not grossly altered. However, coincident knockdown of Ipk1 and IFT88 or IFT57 had synergistic perturbations. With GFP-Ipk1 enriched in centrosomes and basal bodies, we propose that [...]
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Apoptosis 2007,Dec,01;12(12):2197-206; (PMID: 17874297)
[...]) has been shown to interact with DED-containing proteins and to encode pro-apoptotic functions. Here we characterize a novel interaction between Rybp and Hippi, a protein implicated in neuronal apoptosis as well as in the pathogenesis of Huntington's disease[...]
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FEBS J 2007,Aug,01;274(15):3886-99; (PMID: 17623017)
[...] caused by exogenous Hippi, observed earlier in HeLa and Neuro2A cells, in this work we identified a specific motif AAAGACATG (- 101 to - 93) at the caspase-1 gene upstream sequence where HIPPI could bind. Various mutations in this specific sequence compromised the [...]
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