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Results for "Caffeine": Medline ( 22,949 ) | Full Text ( 657 ) | Grants ( 469 )

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Simultaneous quantitation of paracetamol, caffeine, pseudoephedrine, chlorpheniramine and cloperastine in human plasma by liquid chromatography-tandem mass spectrometry.

J Pharm Biomed Anal 2010,Feb,05;51(3):716-22; (PMID: 19879084)
Li, Hao ; Zhang, Chao ; et al.
[...]A rapid and sensitive method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the simultaneous quantitation of paracetamol, caffeine, pseudoephedrine, chlorpheniramine and cloperastine in human plasma has been developed and validated. After sample preparation by liquid-liquid extraction, the analytes and internal standard ([...]

Post-fusion treatment with MG132 increases transcription factor expression in somatic cell nuclear transfer embryos in pigs.

Mol Reprod Dev 2010,Feb,01;77(2):149-57; (PMID: 19813265)
[...] of cloned pig embryos. Immediately after electrofusion, SCNT oocytes were treated with MG132 and/or caffeine for 2 hr, vanadate for 0.5 hr, or vanadate for 0.5 hr followed by MG132[...]

CaM kinase II in colonic smooth muscle contributes to dysmotility in murine DSS-colitis.

Neurogastroenterol Motil 2010,Feb,01;22(2):186-95, e64; (PMID: 19735476)
Qureshi, S ; Song, J ; et al.
[...] with dextran sulphate sodium (DSS) in the drinking water for 5 days. KEY RESULTS: Spontaneous and acetylcholine-evoked contractions, caffeine-evoked hyperpolarization, and SERCA2 and phospholamban expression were reduced compared with controls. Tetrodotoxin did not restore control levels of [...]The amplitudes, but not the frequency, of intracellular Ca(2+) waves were increased compared with controls. Caffeine abolished intracellular Ca(2+) waves in control smooth muscle cells, but not in smooth muscle cells from DSS-treated [...]

Acute atrial arrhythmogenesis in murine hearts following enhanced extracellular Ca(2+) entry depends on intracellular Ca(2+) stores.

Acta Physiol (Oxf) 2010,Feb,01;198(2):143-58; (PMID: 19886909)
Zhang, Y ; Fraser, J A ; et al.
[...] concentrations (1.0 microm) produced sustained and irregular patterns of cytosolic Ca(2+) activity, independent of pacing. Nifedipine (0.5 microm), and caffeine (1.0 mm) and cyclopiazonic acid (CPA) (0.15 microm) pre-treatments respectively produced immediate and gradual reductions in the F/F(0) peaks.[...]

Cell context-dependent involvement of ATR in early stages of retroviral replication.

Virology 2010,Jan,20;396(2):272-9; (PMID: 19913868)
Retroviral DNA integration leaves behind a single-strand DNA discontinuity at each virus:host DNA junction. It has long been proposed that cellular proteins detect and repair the integrated DNA and that failure to do so might lead to apoptotic [...]

Adenosine A3 receptor-mediated cardioprotection against doxorubicin-induced mitochondrial damage.

Biochem Pharmacol 2010,Jan,15;79(2):180-7; (PMID: 19686702)
[...] levels were measured with indo-1 and rhod-2 probes. SR Ca(2+) content was determined by exposing cultured rat cardiomyocytes to caffeine. Echocardiography data demonstrate left ventricular wall thinning (23%), an increase in the end systolic dimension (170%) and decreased fractional shortening (35+/-5% vs. 54+/-5%, p<0.01) in [...]

The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpoint.

J Biol Chem 2010,Jan,15;285(3):1879-87; (PMID: 19917613)
[...] (Tyr(15)), a critical event in the G(2)/M checkpoint. Treatment with the ATM/ATR inhibitor caffeine was unable to prevent PKCdelta-cat-induced G(2)/M arrest, suggesting that PKCdelta-cat is functioning downstream of ATM/ATR in the G(2)/M [...]

Microplasma discharge ionization source for ambient mass spectrometry.

Anal Chem 2010,Jan,15;82(2):621-7; (PMID: 20020764)
[...]The initial performance of the microplasma device has been evaluated by ionizing samples containing dimethyl sulfoxide (DMSO), dimethylformamide (DMF), methyl salicylate, caffeine, l-leucine, l-histidine, loratadine, ibuprofen, acetaminophen, acetylsalicylic acid, and [...]

Chronic caffeine treatment attenuates experimental autoimmune encephalomyelitis induced by guinea pig spinal cord homogenates in Wistar rats.

Brain Res 2010,Jan,14;1309:116-25; (PMID: 19879252)
[...]Dysfunction of adenosinergic systems has been implicated in the development of multiple sclerosis in humans and experimental autoimmune encephalomyelitis (EAE) in animals. Caffeine, a non-selective antagonist of adenosine receptors, has been shown to provide protection against myelin[...]

Characterization of flavor modulating effects in complex mixtures via high temperature liquid chromatography.

J Agric Food Chem 2010,Jan,13;58(1):458-64; (PMID: 19924859)
[...]The eluent containing only water and ethanol was diluted with a basic tastant solution (500 mg L(-1) caffeine and 5% sucrose, respectively) and evaluated by a trained panel by duo comparison tests. This novel method was applied to the known flavor and [...]
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