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Med Hypotheses 2010,Oct,01;75(4):363-7; (PMID: 20409647)
[...]pigmentation of humans. The most prominent environmental explanation is that reduced endogenous vitamin D production due to diminished radiation at higher latitudes had a deleterious impact on fitness. This drove de-[...] as an adaptive response. A model of natural selection explains the high correlations found between low vitamin D levels and ill health, as vitamin D's role in immune response has clear evolutionary implications.[...]
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Curr Rheumatol Rep 2010,Oct,01;12(5):332-6; (PMID: 20680529)
[...]Various factors that conceivably work in conjunction with one another also cause bone loss in AS (eg, genetic polymorphisms of vitamin D, low levels of osteoprotegerin and sex steroid hormones, and impaired calcium and vitamin D absorption). Dual x-ray absorptiometry for assessing [...]
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Curr Opin Cardiol 2010,Sep,01;22(5):513-7; (PMID: 20616710)
[...]PURPOSE OF REVIEW: Vitamin D deficiency is common throughout the world, with a particularly high prevalence in northern latitudes and colder climates.[...]The number of clinical studies has steadily grown in recent years, with the largest number comprising observational studies showing associations between low vitamin D status, the presence of various cardiovascular risk factors, and adverse cardiovascular outcomes.[...]
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Curr Atheroscler Rep 2010,Sep,01;12(5):322-30; (PMID: 20628837)
[...]Genetic risk factors have been identified, including a single nucleotide polymorphism of SLCO1B1. Coenzyme Q10 and vitamin D have been used to prevent and treat statin myopathy; however, clinical trial evidence demonstrating their efficacy is limited.[...]however, clinical trial evidence demonstrating their efficacy is limited. Statin-intolerant patients may be successfully treated with either low-dose statins, alternate-day dosing, or using twice-weekly dosing with longer half-life statins. An algorithm is presented to assist the clinician in managing [...]
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Scand J Prim Health Care 2010,Sep,01;28(3):166-71; (PMID: 20642395)
[...]OBJECTIVE: To investigate vitamin D levels in patients with non-specific musculoskeletal pain, headache, and fatigue. DESIGN: A cross-sectional descriptive study.[...] compared with patients with other symptoms. Some 15% of patients with low (< 50 nmol/L) vitamin D levels reported headaches, compared with 5% of those with normal vitamin D[...]
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Am J Epidemiol 2010,Sep,01;172(5):566-77; (PMID: 20693267)
[...] was associated with high intake of polyunsaturated fats (quartile 4 vs. quartile 1: odds ratio = 2.41, 95% confidence interval (CI): 1.33, 4.38). Dietary calcium was positively associated with low-grade cancer but inversely associated with high-grade cancer (for quartile 4 vs. quartile 1, odds ratios were 1.27 (95% CI: 1.02, 1.57) and 0.43 (95% CI: 0.21, 0.89), respectively).[...]Neither dietary nor supplemental intakes of nutrients often suggested for prostate cancer prevention, including lycopene, long-chain n-3 fatty acids, vitamin D, vitamin E, and selenium, were significantly associated with cancer risk. High intake of n-6 fatty acids, through their effects on [...]
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Eur Spine J 2010,Sep,01;19(9):1545-50; (PMID: 20361340)
[...]Low bone mass and osteopenia have been reported in the axial and peripheral skeleton of adolescent idiopathic scoliosis[...]Furthermore, several recent studies have shown that gene polymorphisms are related to osteoporosis. However, no study has yet linked polymorphisms in the vitamin D receptor (VDR) gene and bone mass in AIS. Accordingly, the authors examined the association between [...]
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Bone 2010,Sep,01;47(3):598-603; (PMID: 20601293)
[...]OBJECTIVES: Low bone mineral density (BMD) is common in children and adolescents with celiac disease. Strict [...] intake were calculated using nutrition data software. EMA, tissue transglutaminase antibodies, serum calcium, phosphate, 25-hydroxy vitamin D, intact parathormone, albumin, urea and creatinine levels were determined in all patients.[...] with total body BMD below -1.0 in not strictly compliant group (71% compared to 38%; p=0.03). Calcium intake and vitamin D levels were below recommendations in both groups. CONCLUSION: Children and adolescents on not strict GFD are at increased risk for low BMD.[...]
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Am J Clin Nutr 2010,Sep,01;92(3):652-9; (PMID: 20610635)
[...]BACKGROUND: Female adolescent runners have an elevated prevalence of low bone mass for agemdashan outcome that may be partially due to inadequate energy intake. OBJECTIVE: The objective was to evaluate diet, [...]DESIGN: Thirty-nine cross-country runners (age: 15.7 plusmn 0.2 y) participated in the study, which included a 7-d dietary assessment with the use of a food record and daily 24-h dietary recalls; serum measures of insulin-like growth factor I, estradiol, leptin, parathyroid hormone, progesterone, [...] concentrations, and a higher prevalence of body mass index lt 10% for age, vitamin D insufficiency, amenorrhea, and low bone mass. Girls with EBT consumed less than the recommended amounts of energy and had a higher prevalence of consuming lt 1300 mg Ca than did those with normal [...]
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Oncogene 2010,Aug,26;29(34):4800-13; (PMID: 20543868)
[...]In this study, we show that SPRY2 expression in colon cancer cells is inhibited by the active vitamin D metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) through E-cadherin-dependent and -independent mechanisms. In turn, SPRY2 represses both basal and 1,25(OH)(2)D(3)-induced [...], SPRY2 is upregulated in undifferentiated high-grade tumours and at the invasive front of low-grade carcinomas. Quantification of protein expression in 34 tumours confirmed an inverse correlation between SPRY2[...]
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