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Canadian Cancer Society (CAN) 2012,Jul,01; (Grant Number: CRIS-CCS-1326)
[...]Breast cancer cells often leave the primary tumour to spread in the body and colonize other organs.[...]It is these secondary tumours which are often the major cause of death of cancer patients. Research in Dr Cote's laboratory uses multidisciplinary approaches (such as biochemistry, cell biology, [...]
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Canadian Cancer Society (CAN) 2012,Jul,01; (Grant Number: CRIS-CCS-1418)
[...]The growth and division of cells is controlled by a network of enzymes known as protein kinases that frequently contribute to tumourigenesis when they become active at the wrong time in cancer cells. Dr Litchfield's research is focused on one group of these protein kinases known as CK2.[...]This group of enzymes is present at abnormally high levels in many forms of human cancer and has been shown to promote breast cancer and leukemia in mice. Dr Litchfield is working to understand how CK2 contributes to the inappropriate division of [...]
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Canadian Cancer Society (CAN) 2012,Jul,01; (Grant Number: CRIS-CCS-1452)
[...]During cancer progression, cells first overcome normal signals that prevent them from multiplying excessively and then later acquire properties that permit them to spread to other parts of the body, a process referred to as [...]The team also showed that Smad2 can cooperate with another group of proteins called TCFs to increase the expression of certain genes. They showed that these genes were increased in mouse and human gastrointestinal and breast cancers, suggesting that the cooperation of Smads with TCFs contributes to tumour progression.[...]Impact and relevance: A better understanding of how Smads work to control TGFbeta signals may lead to new ways to prevent or treat cancer. Category of Research: Fundamental Cancer Site Relevance: Breast & colon/rectum
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Canadian Cancer Society (CAN) 2012,Jul,01; (Grant Number: CRIS-CCS-1462)
[...]. Changes in the regulation of the cell cycle have been found to cause cancer. Dr Nepveu uses mouse and human cells in the laboratory to investigate the progression from one phase to another in the [...], he hopes to find some that could be suitable targets for future therapeutic strategies. Category of Research: Fundamental Cancer Site Relevance: Breast & hematopoietic
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Canadian Cancer Society (CAN) 2012,Jul,01; (Grant Number: CRIS-CCS-1461)
[...]Dr Dedhar has been investigating the molecular basis of how cells convert information from their surrounding microenvironment to regulate their growth, death and movement. Cancer cells differ from normal cells in how they interact and communicate with their microenvironment, resulting in more rapid and sustained [...]-regulated processes, and the eventual development of more effective cancer therapeutics.Category of Research: Fundamental Cancer Site Relevance: Breast, lung, prostate & various other sites
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Canadian Cancer Society (CAN) 2012,Jul,01; (Grant Number: CRIS-CCS-26)
[...]Unfortunately, it is now clear that from time-to-time activators have been found to work at the wrong time or to stop working altogether and this scenario is seen in a number of different forms of cancer. With his research team, Dr Omichinski is studying how activators function in the normal setting and how disruption of their normal functions leads to the development of [...]Impact and relevance: Activators all serve different functions, but they have all been shown to be associated with cancer including colon cancer, lung cancer, breast cancer, and many forms of leukemia. Understanding the differences between these various activators is crucial for understanding how to design specific therapies for these different [...]
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Canadian Cancer Society (CAN) 2011,Jul,01; (Grant Number: CRIS-CCS-080583)
[...]Dr. Huntsman's group is studying a gene that is often altered in families with an inherited tendency to develop stomach cancer. Relevance: Stomach cancer is the second leading cause of cancer death worldwide. Most cases are due to environmental factors such as diet or infection, but some [...]Dr. Huntsman's team is studying a gene that is often altered in families with an inherited tendency to develop stomach cancer, and may also be responsible for some inherited breast cancers. More information about this gene alteration will help families affected by it to prevent and treat this dangerous [...]
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Canadian Cancer Society (CAN) 2011,Jul,01; (Grant Number: CRIS-CCS-081882)
[...]Dr. Bleackley's group is studying immune system cells that can destroy cancer cells, and how they accomplish this. Relevance: Immune system cells known as cytotoxic T lymphocytes (CTLs) protect the body against various threats and are known to be involved in the destruction of [...] cells to see whether activity of certain genes is affecting their ability to avoid self-destruction. Category of Research: Fundamental Cancer Site Relevance: Brain/neurological, skin/integument & breast
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Canadian Cancer Society (CAN) 2011,Jul,01; (Grant Number: CRIS-CCS-081424)
[...]Dr. Penn's team is studying a protein that contributes to the development of cancer when it occurs in abnormally high numbers inside a cell. Relevance: A protein called Myc[...] proteins, since this information can help patients and doctors making treatment decisions. Category of Research: Fundamental Cancer Site Relevance: Breast, hematopoietic & various other sites
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Canadian Cancer Society (CAN) 2011,Jul,01; (Grant Number: CRIS-CCS-1325)
[...]Breast cancer cells often leave the primary tumour to spread in the body and colonize other organs.[...]It is these secondary tumours which are often the major cause of death of cancer patients. Research in Dr Cote's laboratory uses multidisciplinary approaches (such as biochemistry, cell biology, [...]
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