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Mol Cell Biol 2010,Apr,01;30(7):1689-702; (PMID: 20086096) [FULL TEXT AVAILABLE] [...]Here we investigated a multimodular protein termed PXK, composed of a PX domain, a protein kinase-like domain, and a WASP homology 2 domain. We show that the PX domain of PXK[...]
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Mol Cell Biochem 2010,Jan,01;334(1-2):81-98; (PMID: 19941037) [...], consists of an extracellular ligand-binding domain, a single transmembrane domain, and an intracellular cytoplasmic region containing a protein kinase-like homology domain (KHD) and a guanylyl cyclase (GC) catalytic domain. After binding with atrial and [...]
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Structure 2009,Dec,09;17(12):1649-59; (PMID: 20004168) [...]The LinB structure provides an evolutionary link to ancient nucleotide polymerases and suggests that, like protein kinases and acetyltransferases, these are proto-resistance elements from which drug resistance can evolve.
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Apoptosis 2009,Nov,01;14(11):1366-77; (PMID: 19771520) [...] in a dose-responsive manner, and these effects were associated with a corresponding increase in poly (ADP-ribose) polymerase (PARP)-cleavage and activation of protein kinase-like endoplasmic reticulum kinase/eukaryotic translational initiation factor/activating transcription factor 4 (PERK/eIF2alpha/ATF-4) pathway, a marker of ER stress response[...]
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J Pharmacol Exp Ther 2009,May,01;329(2):808-19; (PMID: 19188481) [...]) stress, as indicated by changes in cytosol-calcium levels, double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase phosphorylation, inositol-requiring protein 1 (IRE1) and CHOP/GADD153 up-regulation, X-box transcription factor-1 [...]
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Biochim Biophys Acta 2008,Jan,01;1784(1):106-15; (PMID: 17920343) [...] motif; 15-30 min); second, the phosphorylation of MEK (extracellular signal regulated kinase [ERK] kinase)-like proteins (30-60 min) and then that of the threonine-glutamate-tyrosine motif (>1 h); finally, the late tyrosine[...]
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J Cell Biochem 2007,May,01;101(1):99-111; (PMID: 17177295) [...]SGLT1 molecules at the enterocyte plasma membrane through a mechanism in which several protein-like kinases are involved.
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J Endocrinol 2007,Apr,01;193(1):65-74; (PMID: 17400804) [...]Bip), inositol-requiring enzyme-1alpha, X-box-binding protein-1 (XBP-1), RNA-activated protein kinase-like endoplasmic reticulum kinase, activating transcription factor-4, and C/EBP-homologous protein (CHOP) were more expressed in the transgenic islets.[...]
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Cell Signal 2007,Feb,01;19(2):238-50; (PMID: 16963228) The recent identification of tribbles as regulators of signal processing systems and physiological processes, including development, together with their potential involvement in diabetes and cancer, has generated considerable interest in these proteins. Tribbles have been reported to regulate activation of a number of intracellular [...]
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Oncogene 2007,Feb,01;26(5):725-32; (PMID: 16878153) [...]-/- MEFs grew faster than wt MEFs. This agreed with elevated levels of cell cycle mediators like extracellular signal-regulated protein kinase, p38, AP1 and Cyclin D1. Infection with a uPAR retrovirus reverted the effect, decreasing the growth rate.When MEFs were transformed with H-Ras(V12) and E1A oncogenes, the efficiency of transformation in [...]
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