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Invest New Drugs 2010,Oct,01;28(5):575-86; (PMID: 19636513)
[...]12-O-tetradecanoylphorbol-13-acetate), and the novel compound PEP008 (20-O-acetyl-ingenol-3-angelate) in cell lines derived from melanoma, breast cancer and colon cancer. The diterpene esters induced permanent growth arrest with characteristics of senescence[...]
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Cancer Lett 2010,Oct,01;296(1):35-42; (PMID: 20381234)
[...]Inflammation is known to be closely associated with the development of cancer. Decursinol angelate (DA), a coumarin compound isolated from Angelica gigas and related compounds have been shown to possess potent anti-inflammatory activities.[...] molecules and matrix metalloproteinase (MMP)-9. DA inhibited the invasion of fibrosarcoma cell line, HT1080 and breast cancer cell line, MDA-MB-231 in the Matrigel invasion assay. DA-mediated suppression of cancer cell invasion was accomplished by suppression of [...]
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Cancer Lett 2010,Oct,01;296(1):74-87; (PMID: 20417028) [FULL TEXT AVAILABLE]
[...]Akt and mTOR are therapeutic targets for the treatment of cancer. The effects of inhibiting mTOR, with rapamycin, and Akt, with A-443654, concurrently, on cell morphology, [...]cell cycle, and apoptosis were examined using the benign MCF10A and malignant MCF10CA1a human breast epithelial cells. Rapamycin and A-443654 in combination produced the greatest morphological changes and inhibited cell proliferation[...]
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J Cell Physiol 2010,Oct,01;225(1):168-73; (PMID: 20458733)
[...]Angiotensin II (Ang II) is a bioactive peptide of the renin-angiotensin system, acting not only as a vasoconstrictor but also as a growth promoter via angiotensin II type 1 receptor (AT1R) in some cancer. In this study, we examined the mechanisms by which Ang II affected the cell proliferation[...]In this study, we examined the mechanisms by which Ang II affected the cell proliferation in AT1R-positive MCF-7 human breast cancer cells. Ang II stimulated the growth of breast cancer cells in a dose- and time-dependent manner.[...]
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J Cell Physiol 2010,Oct,01;225(1):20-6; (PMID: 20506392)
[...]The importance of transcription factors of Smad family, of forkhead transcription factor (Fox) family, of breast cancer-associated genes/transcription factor, hypoxia-induced transcription factors and of other transcription factors in control of these processes has been demonstrated.[...]
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Appl Radiat Isot 2010,Oct,01;68(10):1980-7; (PMID: 20472453)
[...]The procedures for extracting diffraction patterns from the data and the corrections applied are discussed. The procedures were applied to the characterization of breast tissue samples, 6mm in diameter. Comparison with histological sections of the samples confirmed the possibility of grouping the patterns into five families, corresponding to [...]Comparison with histological sections of the samples confirmed the possibility of grouping the patterns into five families, corresponding to adipose tissue, fibrosis, poorly differentiated cancer, well differentiated cancer and benign tumour.
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Cancer Lett 2010,Oct,01;296(1):9-16; (PMID: 20579805)
Gene microarray is a powerful platform to investigate the expression patterns of thousands of genes simultaneously. One central objective of such analysis is to select sets of genes (i.e., gene signatures) which correlate with clinical characteristics, such as disease subtype diagnosis, response to drug treatment and prognosis.[...]
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Cancer Lett 2010,Oct,01;296(1):17-26; (PMID: 20378243)
[...] factor and the activated HIF plays pivotal roles in various pathological conditions, including inflammation and cancer. HIF-1alpha overexpression has been observed in many common human cancers, including brain, [...]HIF-1alpha overexpression has been observed in many common human cancers, including brain, breast, colon, lung, ovary, and prostate, and HIF-mediated genes, such as vascular [...]
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Int J Cancer 2010,Oct,01;127(7):1718-26; (PMID: 20073065)
[...]Long-term treatment with tamoxifen (TAM) increases the risk of developing endometrial cancer in women. Several antiestrogens developed in last decades have been discontinued from clinical testing because of their undesirable effects on the [...]Several antiestrogens developed in last decades have been discontinued from clinical testing because of their undesirable effects on the uterus. To avoid such serious side-effect while increasing the drug's anti-breast cancer potential, new triphenylethylene antiestrogens, 2E-3-{4-[(E)-4-chloro-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]-phenyl} acrylic acid (SS1020) and 2E-3-{4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenyl}acrylic acid (SS1010), were designed as safer alternatives.[...]
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J Cancer Res Clin Oncol 2010,Oct,01;136(10):1557-62; (PMID: 20169362)
PURPOSE: Limited information exists about the occurrence and the impact of perineural invasion (PNI) in patients with cervical carcinoma (CX). METHODS: The original histologic slides from patients primarily treated by radical hysterectomy and systematic pelvic lymphadenectomy were re-examined regarding the occurrence of PNI.[...]
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