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Seizure 2006,Jun,01;15(4):221-6; (PMID: 16546410)
[...]generalized symptomatic epilepsies, frequent seizures, high antiepileptic drug use, and early onset of epilepsy appear at risk, although psychosocial factors may also play an important role. Five of the six prospective studies on adults report evidence of a mild decline in [...]Five of the six prospective studies on adults report evidence of a mild decline in cognition in patients with a (longstanding) history of pharmacoresistant epilepsy. The adverse effect on cognitive abilities, memory in particular, seems somewhat more robust than that on measures of intelligence.[...]
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J Neurol Neurosurg Psychiatry 2005,Dec,01;76(12):1686-92; (PMID: 16291894)
BACKGROUND AND OBJECTIVES: Brain tumours responsible for longstanding partial epilepsy are characterised by a high prevalence of dysembryoplastic neuroepithelial tumour (DNT), whose natural evolution is much more benign than that of [...]
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Brain 2005,Jul,01;128(Pt 7):1546-55; (PMID: 15817514)
[...]A 3.5-year follow-up study of cognition and behaviour in 42 children with newly diagnosed idiopathic or cryptogenic epilepsy ('epilepsy only') attending mainstream education and 30 healthy gender-matched classmate controls was carried out to identify differences between groups, to detect factors that contribute to the difference and its change over time, and to establish the proportion of poorly performing [...]Based on parental interviews at the time of diagnosis, children with epilepsy were categorized as having longstanding behavioural and/or learning problems, as belonging to a troubled family, as being exposed to 'off-balance' parenting starting at the time of [...]
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Epilepsy Behav 2005,Jun,01;6(4):473-87; (PMID: 15878308)
This review addresses language function and reorganization associated with various forms of epilepsy. Longstanding epilepsy, particularly types with onset early in life, may be associated with changes in the representation of language function in the [...]
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Clin Neurol Neurosurg 2005,Feb,01;107(2):147-51; (PMID: 15708233)
[...] test (Wada test) currently represents the gold standard for preoperative lateralization of hemispheric dominance. Here, we report an epileptic patient with a longstanding extended lesion of the left hemisphere showing absence of motor and speech dysfunction with left carotid amobarbital injection, but tetraplegia and speech arrest with right carotid [...]
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J Clin Neurosci 2005,Feb,01;12(2):128-33; (PMID: 15749411)
[...]PURPOSE: To report 3 cases with focal lesional epilepsy that had non-convulsive status epilepticus (NCSE) induced by treatment with tiagabine (TGB[...]All previously reported cases in the English medical literature were reviewed. RESULTS: The three patients had longstanding complex partial and secondarily generalised seizures refractory to multiple different anti-epileptic drugs. In two cases, MRI demonstrated a focal [...]
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Clin Genet 2004,Dec,01;66(6):545-9; (PMID: 15521983)
[...]His only sibling, a brother born in 2000 was similarly but more severely affected. The boys' mother had longstanding disseminated lupus erythematosus and epilepsy, for which she had been treated with chloraquine and other therapeutic agents during both [...]
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Epilepsy Behav 2003,Oct,01;4(5):537-47; (PMID: 14527496)
[...]) was shown to be very efficacious and well tolerated as add-on therapy for refractory epilepsy. Here we report 33 patients with longstanding histories of epilepsy who experienced aggressive episodes during LEV therapy. This corresponds to 3.5% of LEV-treated [...]
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Acta Physiol Hung 2003,Jan,01;90(4):281-303; (PMID: 14708871)
[...]Positron emission tomography (PET) is a powerful clinical and research tool that, in the past two decades, has provided a great amount of novel data on the pathophysiology and functional consequences of human epilepsy. PET studies revealed cortical and subcortical brain dysfunction of a widespread brain circuitry, providing an unprecedented insight in the complex functional abnormalities of the [...] PET abnormalities with electroclinical variables helped identify parts of this circuitry, some of which are directly related to primary epileptogenesis, while others, adjacent to or remote from the primary epileptic focus, may be secondary to longstanding epilepsy. PET studies have also provided detailed data on the functional anatomy of cognitive and behavioral abnormalities associated with [...]
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J Rheumatol 2003,Jan,01;30(1):193-5; (PMID: 12508412)
[...] with linear scleroderma en coup de sabre and a longstanding clinical history of tonic and clonic convulsions. Radiographic study showed extensive cerebral calcifications in the right occipital hemisphere, homolateral to the involved side of her face.[...] imaging studies should be routinely performed in scleroderma patients exhibiting neurological manifestations, especially seizure disorder.
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