|
|
|
|
Biostatistics 2007,Apr,01;8(2):414-32; (PMID: 16928955)
As much of the focus of genetics and molecular biology has shifted toward the systems level, it has become increasingly important to accurately extract biologically relevant signal from thousands of related measurements. The common property among these high-dimensional biological studies is that the measured features have a rich and largely unknown underlying structure. One example of much recent interest is identifying differentially expressed genes in comparative microarray experiments.[...]
|
|
|
Eur J Cancer 2007,Mar,01;43(5):867-76; (PMID: 17307353)
[...]The prognostic impact of the classical tumour and treatment factors in hereditary BC is insufficiently known. METHODS: We selected 103 BRCA2-, 223 BRCA1- and 311 non-BRCA1/2 BC patients (diagnosis 1980-2004) from the Rotterdam Family Cancer Clinic. To correct for longevity bias, analyses were also performed while excluding index [...]
|
|
|
Radiology 2007,Mar,01;242(3):698-715; (PMID: 17244718)
[...]informed written consent was obtained. CBE, mammography, US, and MR imaging were performed for yearly screening of BRCA1 or BRCA2 mutation carriers, first-degree relatives of BRCA1 or BRCA2 mutation carriers, or women enrolled because of a strong family history of [...]
|
|
|
Br J Cancer 2007,Jan,15;96(1):118-25; (PMID: 17213827) [FULL TEXT AVAILABLE]
The BRCA1 gene product helps to maintain genomic integrity through its participation in the cellular response to DNA damage: specifically, the [...]
|
|
|
Fam Cancer 2007,Jan,01;6(4):473-82; (PMID: 17636425)
[...]CONTEXT: Models have been developed to predict the probability that a person carries a detectable germline mutation in the BRCA1 or BRCA2 genes. Their relative performance in a clinical setting is unclear. OBJECTIVE: To compare the performance characteristics of four [...]
|
|
|
BMC Cancer 2007,Jan,01;7:83; (PMID: 17504528) [FULL TEXT AVAILABLE]
BACKGROUND: Inactivating and truncating mutations of the nuclear BRCA1-interacting protein 1 (BRIP1) have been shown to be the major cause of Fanconi anaemia and, due to subsequent alterations of BRCA1 function, predispose to [...]
|
|
|
BMC Cancer 2007,Jan,01;7:85; (PMID: 17511879) [FULL TEXT AVAILABLE]
BACKGROUND: The breast cancer susceptibility gene, BRCA1, is implicated in multiple cellular processes including DNA repair, the transactivation of genes, and the [...]
|
|
|
BMC Cancer 2007,Jan,01;7:160; (PMID: 17697367) [FULL TEXT AVAILABLE]
[...]An additional recruitment category includes women aged 41 to 50 years who are found to be BRCA1 or BRCA2 gene carriers and were diagnosed with their first breast cancer during the study recruiting period.[...]
|
|
|
Int J Biochem Cell Biol 2007,Jan,01;39(1):220-6; (PMID: 17005433)
BRCA1 is a nuclear phosphoprotein that plays a key role in many cell functions, including DNA repair[...]
|
|
|
Lancet Oncol 2007,Jan,01;8(1):26-34; (PMID: 17196508)
[...], on the risk of ovarian cancer in women who carry a mutation in the BRCA1 or BRCA2 genes. METHODS: We did a matched case-control study in women who were found to carry a pathogenetic mutation in [...]
|
|
|
