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J Public Health Dent 2010,Dec,21;70(1):52-7; (PMID: 19694933)
[...]OBJECTIVES: To examine whether denture use and recurrent sores caused by ill-fitting dentures are associated with intra-oral squamous cell carcinoma (IO-SCC) in individuals exposed to tobacco. METHODS: We conducted a hospital-based case-control study.[...]CONCLUSIONS: The association between recurrent oral sores caused by ill-fitting dentures and squamous cell carcinoma of the mouth in smokers is in agreement with the hypothesis that the chronic physical irritation[...]
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Auris Nasus Larynx 2010,Oct,01;37(5):648-50; (PMID: 20417042)
[...]the variable association reported in literature may be due to wide range of HPV genotypes. We report the case of a 51-year-old man affected by laryngeal squamous cell carcinoma; analysis of DNA extracted by cancer cells by an innovative molecular virology assay (INNO-LiPA HPV Genotyping Extra) showed the presence of two high-risk HPV genotypes, HPV-73 and -82.[...]
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Invest New Drugs 2010,Oct,01;28(5):677-83; (PMID: 19649772)
BACKGROUND: Sunitinib is an orally administered multitargeted tyrosine kinase inhibitor of RET, VEGFR, PDGFR, and c-KIT. We conducted a phase II trial to evaluate the tolerability and efficacy of [...]
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Cancer Lett 2010,Oct,01;296(1):113-22; (PMID: 20457486)
[...] were detected upon methylseleninic acid (MSA) treatment in human esophageal squamous cell carcinoma cell lines EC9706 and KYSE150. MSA reduced beta-catenin protein levels, while there was no significant change observed on [...]
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Cancer Immunol Immunother 2010,Oct,01;59(10):1503-9; (PMID: 20582589)
[...] production and proliferation capacity of NKT cells were analyzed before and after 50 Gy radiation therapy in 12 patients with stage IV head and neck squamous cell carcinoma. The cytotoxic activity of NKT cells was examined in vitro. RESULTS: The number of NKT cells in the [...]
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Cancer Immunol Immunother 2010,Oct,01;59(10):1561-8; (PMID: 20577877)
The TP53 tumor suppressor gene contains a well-studied polymorphism that encodes either proline (P) or arginine (R) at codon 72, and over half of the world's population is homozygous for [...]
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Cancer Lett 2010,Sep,28;295(2):154-66; (PMID: 20363070)
[...] on intricately regulated endogenous antioxidant defense against MOS during radiosensitization by this combination. Two human tumor cell lines {Head and Neck Squamous carcinoma (KB) and Glioma (BMG-1)} and one non-malignantly transformed cell line (human embryonic kidney, HEK) were used in this study.[...]
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Cancer Lett 2010,Sep,28;295(2):135-43; (PMID: 20418015)
[...]Other molecules that have been implicated in drug resistance include multidrug resistance-associated proteins, glutathione S-transferase-pi, and DNA topoisomerase II. These molecules, however, cannot fully explain MDR in oral squamous cell carcinoma. Vacuolar ATPase (V-ATPase), which is largely responsible for regulating acidity in the microenvironment of [...]
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Toxicon 2010,Sep,15;56(4):508-20; (PMID: 20493203)
Cardiotoxin III (CTX III), a basic polypeptide with 60-amino acid residues isolated from Naja naja atra venom, has been reported to have cytotoxic activity. CTX III exerted cytotoxicity with the S-phase cell cycle arrest, correlated with a marked decrease in the expression levels of [...]
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J Photochem Photobiol B 2010,Sep,02;100(3):173-80; (PMID: 20599390)
[...] in terms of: (i) cytotoxicity without illumination, (ii) phototoxicity, (iii) cellular uptake and release, and (iv) apoptosis induction in A431 human epidermoid carcinoma cells using comparable illumination regimens. We clearly show that meso-tetrahydroxyphenylchlorin (mTHPC, Foscan) is a very effective photosensitizer inducing high phototoxicity at very low concentrations.[...]
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