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Mol Reprod Dev 2010,Feb,01;77(2):136-48; (PMID: 19834983)
[...] preparations were pre-incubated with inhibitors of specific signaling molecules, followed by incubation with ouabain. The phosphotyrosine content of sperm preparations was determined by immunoblotting, and capacitation status of these sperm preparations were evaluated through an [...]
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Clin Exp Immunol 2010,Feb,01;159(2):176-84; (PMID: 19919568)
[...] serum including anti-CD22 autoantibodies for CD22 tyrosine phosphorylation was examined by Western blotting using phosphotyrosine-specific antibodies reacting with four major tyrosine motifs of CD22 cytoplasmic domain. Anti-CD22 autoantibodies were positive in 80% of TSK/+ [...]
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Cancer Res 2010,Jan,15;70(2):666-74; (PMID: 20068168)
[...] that were suppressed by rapamycin, subsequently decreasing levels of pAkt-Ser(473) through effects on phosphotyrosine phosphatase SHP-1. Octreotide potentiated the antiproliferative effects of rapamycin in immortalized pituitary tumor cells or [...]
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FEBS Lett 2010,Jan,04;584(1):33-8; (PMID: 19914245)
[...]MAVS interacted with c-Abl through its Card and TM domain. A phosphotyrosine-specific antibody indicated that MAVS was phosphorylated by c-Abl. Functional impairment of c-Abl attenuated MAVS or VSV induced type-I IFN production.[...]
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Annu Rev Pharmacol Toxicol 2010,Jan,01;50:215-35; (PMID: 20055703)
[...] also render them highly susceptible to oxidative and electrophilic inactivation by a broad spectrum of structurally disparate xenobiotic compounds. The loss of PTP activity results in a profound disregulation of protein phosphotyrosine metabolism, leading to widespread and persistent activation of signaling cascades in the cell.
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Hum Reprod 2010,Jan,01;25(1):29-36; (PMID: 19801569)
[...] antibody under capacitating conditions and with A23187. The effects of the antibody were evaluated on sperm motility, protein phosphotyrosine content and free intracellular calcium. RESULTS: Immunofluorescence results demonstrated that eppin is located on the [...]
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Mol Cell Proteomics 2010,Jan,01;9(1):84-99; (PMID: 19770167)
[...]The latter is often an issue as typically several milligrams of (stable isotope-labeled) starting protein material are required to enable the detection of low abundance phosphotyrosine peptides. Here, we adopted and refined a peptidecentric immunoaffinity purification approach for the quantitative analysis of [...]
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Dev Comp Immunol 2010,Jan,01;34(1):42-8; (PMID: 19686773)
[...] family domains in EsSOCS2, including an N-terminal ESS formed from a single amphipathic helix, a central SH2 domain with a classic phosphotyrosine (pY) site and a C-terminal SOCS box. The sequence and structural similarity of EsSOCS2 with [...]
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J Biol Chem 2009,Dec,25;284(52):36700-10; (PMID: 19843520) [FULL TEXT AVAILABLE]
[...] is activated by the cytoskeletal protein talin via direct binding of its phosphotyrosine-binding-like F3 domain to the cytoplasmic tail of the beta integrin subunit. The phosphotyrosine-binding domain of the signaling protein Dok1[...]
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J Am Chem Soc 2009,Dec,23;131(50):18186-90; (PMID: 19924991)
[...] while effectively discriminating against similar peptides containing unmodified tyrosine (160-fold), sulfotyrosine (3600-fold), phosphotyrosine (>8000-fold), and phosphoserine (>8000-fold). The isolation of endopeptidase variants that can discriminate between substrates based on the post-translational modification[...]
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