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J Pharm Biomed Anal 2010,Sep,21;53(1):29-36; (PMID: 20381986)
[...]A mid-infrared transmission spectroscopic method with the possibility of high sample throughput was developed and validated on the basis of GMP requirements for protein therapeutics. In comparison with the method predominantly used, i.e. the surface-sensitive attenuated total reflection (ATR), we have shown that transmission measurements in solution possess several advantages, such as quantitative analysis on the basis of Lambert-Beer's law, determination of identity and purity based on specifically developed identity criteria, characterization of protein structure and structural changes including aggregation in solution and study of [...]
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Eur J Pharmacol 2010,Sep,10;642(1-3):121-7; (PMID: 20540939)
[...]Results obtained with L-NNA, 1400W, 7-NI, OxyHb, ODQ or Tiron showed that this response was mediated by products from endothelial NOS (eNOS) different from NO and without soluble guanylate cyclase activation, but it involved superoxide anions. Furthermore, Tiron or L-NNA reduced the levels of reactive [...]
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Eur J Pharmacol 2010,Sep,10;642(1-3):140-5; (PMID: 20638948)
[...] product), dimanganese decacarbonyl (DMDC, CO donor) or zinc protoporphyrin IX (ZnPP IX, HO-1 antagonist). Another group received soluble guanylate cyclase (sGC) inhibitor (ODQ) 30 min before hemin, biliverdin or DMDC. After 30 min, gastric[...]
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Comp Biochem Physiol B Biochem Mol Biol 2010,Sep,01;157(1):33-8; (PMID: 20451652)
[...] elevated E20M activity. In vivo, the 50-fold increase in E20M activity was diminished by injections of guanylate cyclase inhibitors alone or combined with RH-5849. Guanylate cyclase inhibitor effects were significantly diminished when co-injected with dibutyryl [...]
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Comp Biochem Physiol A Mol Integr Physiol 2010,Sep,01;157(1):28-34; (PMID: 20488253)
[...], the H2O2 scavenger PEG-catalase, the nitric oxide synthase inhibitor L-NAME, or the soluble guanylate cyclase inhibitor ODQ. Enzyme immunoassay determined that, under basal conditions, the chicken DA produced PGE2[...]
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Pharmacol Biochem Behav 2010,Sep,01;96(3):306-11; (PMID: 20566406)
[...]In the present study, we investigated the anxiolytic effect of GBPs - by Guanosina Monophosphate (GMP) administration - in rodents. Adult male Wistar rats were pretreated with GMP[...]
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Eur J Pharmacol 2010,Aug,25;640(1-3):94-101; (PMID: 20444426)
[...] stimulate the activity of BKCa and KV channels due to PKG activation and suggest that this hormone relaxes by activating particulate guanylate cyclase which increases the cGMP intracellular level.
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Org Biomol Chem 2010,Aug,21;8(16):3621-3; (PMID: 20571620)
[...]The triplet aryl cation photochemically generated from fluoroquinolones bearing a fluoro atom at position 8 attacks guanosine monophosphate (k(r) > 10(9) M(-1)s(-1)) and forms covalent adducts. The reaction is a model for the implementation of oxygen-independent [...]
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J Chromatogr A 2010,Aug,06;1217(32):5197-203; (PMID: 20580011)
[...]/ESI-APCI-TOF-MS) method is described for the rapid determination of five monophosphate nucleotides (cytidine 5'-monophosphate, uridine 5'-monophosphate, adenosine 5'-monophosphate, inosine 5'-monophosphate and guanosine 5'-monophosphate) in baby foods. The method is based on the deproteinisation of foods and direct analysis of nucleotides by ion-pair [...]
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Inorg Chem 2010,Aug,02;49(15):7197-215; (PMID: 20586416)
[...] (His) ligand and NO. This is key for the activation of the NO sensor soluble guanylate cyclase. Finally, DFT methods are calibrated against the experimentally determined vibrational properties of the Fe-N-O subunit in 1.[...]
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