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Int J Cancer 2010,Feb,15;126(4):852-63; (PMID: 19626588)
[...] (MTT) assay and isobologram analysis. delta-TT exhibited a similar inhibitory action when combined with ATST. Mevalonate and geranylgeranyl pyrophosphate eliminated most of the growth inhibitory effect of ATST, but only marginally decreased that of [...]
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Biochem Pharmacol 2010,Feb,15;79(4):647-54; (PMID: 19782050)
[...] was linked to the degree of cholesterol synthesis inhibition and GTP-binding protein unprenylation. Moreover, co-incubation with mevalonate or geranyl-geranyl pyrophosphate, products of HMG-CoA reductase, reversed the inhibitory effect of statins on cellular accumulation and cytotoxicity of [...]
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Appl Microbiol Biotechnol 2010,Feb,01;85(5):1463-72; (PMID: 19690851)
Based on comparative amino-acid sequence alignment of geranylgeranyl diphosphate (GGPP) synthase from filamentous fungi, degenerated oligonucleotide primers were designed for searching GGPP[...]
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J Bacteriol 2010,Jan,01;192(1):198-207; (PMID: 19880605) [FULL TEXT AVAILABLE]
[...] constants (K(I)s) of 0.3 mM and 1.14 mM in the presence of sufficient geranylgeranyl pyrophosphate (GGPP) and phytyl pyrophosphate (PPP), respectively. Surprisingly, the bacteriochlorophyll synthase of Rhodobacter sphaeroides[...]
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Cytokine 2010,Jan,01;49(1):45-50; (PMID: 19932975)
[...] induced a significant reduction in LSEC viability, in a dose dependent manner, under serum-containing or serum-free conditions. This effect was prevented by mevalonate and GGPP, indicating the role of hydroxy-3-methylglutaryl-CoA reductase. The simvastatin effect on LSEC death was not associated with increased activation of [...]
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J Biol Chem 2009,Dec,18;284(51):35368-80; (PMID: 19776008) [FULL TEXT AVAILABLE]
[...]We had previously shown that alterations in cellular levels of the 15-carbon sterol pathway intermediate farnesyl pyrophosphate (FPP) cause increased Hmg2p ubiquitination and degradation. We now present evidence that the [...] and degradation. We now present evidence that the FPP-derived, 20-carbon molecule geranylgeranyl pyrophosphate (GGPP) is a potent endogenous regulator of Hmg2p degradation. This work was launched by the unexpected observation that [...]
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J Plant Physiol 2009,Dec,15;166(18):1961-7; (PMID: 19581023)
[...] are present. However, despite the pharmacological importance of these compounds, specific information about their biosynthesis and localization in the plant is not available. In this investigation, we followed the metabolic transformation of a tritium-labeled diterpene-precursor via geranylgeranyl diphosphate into each of the three diterpenes. Inhibitors of gibberellin biosynthesis were used to elucidate the sequence of conversion of the intermediates. Our results suggest the biosynthetic conversion of [...]
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Cell Mol Life Sci 2009,Dec,01;66(23):3685-95; (PMID: 19633972)
[...]The reactions leading to the production of geranyl diphosphate (C10), farnesyl diphosphate (C15) and geranylgeranyl diphosphate (C20), which are the precursors of mono-, sesqui- and diterpenes, respectively, are catalyzed by a group of highly conserved enzymes known as short-chain isoprenyl diphosphate synthases, or prenyltransferases.[...]
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Br J Pharmacol 2009,Dec,01;158(7):1777-86; (PMID: 19888963) [FULL TEXT AVAILABLE]
[...]They also decrease the synthesis of isoprenoid molecules, such as the side chain of ubiquinone and geranylgeranyl pyrophosphate. As a consequence, statins impair mitochondrial metabolism and the activation of small monomeric GTPases (such as [...]
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Horm Metab Res 2009,Dec,01;41(12):861-5; (PMID: 19672814)
[...]mevalonate kinase mRNA levels. PTH-induced BMP-2 mRNA upregulation was selectively reversed by geranylgeranyl pyrophosphate (GGPP) pretreatment, but not by mevalonate pretreatment. These findings suggest that BMP-2 mRNA expression[...]
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