|
|
|
|
Hypertension 2010,Sep,01;56(3):445-52; (PMID: 20644009)
[...]posttranslational modification of several proteins, such as Rho by mevalonate-derived isoprene groups, geranylgeranyl pyrophosphate or farnesyl pyrophosphate, underlie the pleiotropic effects of statins, the detailed mechanisms remain elusive.[...]
|
|
|
FEBS J 2010,Sep,01;277(17):3588-95; (PMID: 20670276)
[...] with highest abundance in Mtb has a mass fragmentation pattern identical to edaxadiene, which is produced in vitro from geranylgeranyl diphosphate by the enzymes Rv3377c and Rv3378c. A second diterpene found in Mtb has a similar mass spectrum, and is always observed in the same proportion relative to edaxadiene, indicating that it is a side product of the Rv3378c reaction in vivo.[...]
|
|
|
Oncogene 2010,Aug,19;29(33):4682-92; (PMID: 20562912)
[...]The effects of lovastatin on EGFR function were reversed by the addition of geranylgeranyl pyrophosphate, which functions as a protein membrane anchor. Lovastatin treatment induced actin cytoskeletal disorganization and the expression of geranylgeranylated rho family proteins that regulate the actin [...]
|
|
|
Proc Natl Acad Sci U S A 2010,Aug,03;107(31):13654-9; (PMID: 20643967) [FULL TEXT AVAILABLE]
[...]dimethylallyl diphosphate precursors and reprogrammed the rate-limiting downstream pathway by generating combinatorial mutations in geranylgeranyl diphosphate synthase and levopimaradiene synthase. The mutant library contained pathway variants that not only increased diterpenoid production but also tuned the selectivity toward [...]
|
|
|
Biochim Biophys Acta 2010,Aug,01;1801(8):896-905; (PMID: 20382260)
[...]Isoprenoids are a complex class of biologically active lipids including for example, dolichol, ubiquinone, farnesylpyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP). Early work had shown that the long-chain isoprenoid dolichol is decreased but that [...]
|
|
|
Cardiovasc Res 2010,Jul,15;87(2):385-93; (PMID: 20045866)
[...]METHODS AND RESULTS: The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin suppressed basal and cytokine-treated EL expression in endothelial cells. Concomitant treatment with mevalonate or geranylgeranyl pyrophosphate completely reversed the inhibitory effect of pitavastatin, suggesting that geranylgeranylated proteins are involved in the [...]
|
|
|
Phytochemistry 2010,Jul,01;71(10):1115-21; (PMID: 20452633)
[...]To evaluate the defensive value of these HGL-DTGs, we used virus-induced-gene silencing to reduce the transcript levels of geranylgeranyl diphosphate synthase and total HGL-DTG levels in both species. When fed on silenced plants, larvae gained up to about two times more mass than those that fed on empty vector control plants of both species.[...]
|
|
|
Eur J Hum Genet 2010,Jul,01;18(7):844-7; (PMID: 20179743)
[...], and nonsterol-isoprenoids biosynthesis. The shortage of mevalonate-derived intermediates, and in particular of geranylgeranyl pyrophosphate (GGPP), has been linked with the activation of caspase-1 and thereby with the production of IL-1beta, but the true concatenation of these two events has not been clarified yet.[...]
|
|
|
Appl Microbiol Biotechnol 2010,Jul,01;87(3):1077-88; (PMID: 20393706)
A gene (ggs2) having high similarity to the geranylgeranyl diphosphate synthase (GGPP synthase) gene was cloned from Metarhizium anisopliae NAFF635007. The ggs2 gene (1,239-bp open reading frame with no intron) encoded a protein of 412 amino acids, and the [...]
|
|
|
Cell Mol Neurobiol 2010,Jul,01;30(5):727-35; (PMID: 20127168)
[...]The increase in TEER was significantly reduced in the presence of isoprenoid geranylgeranyl pyrophosphate, whereas farnesyl pyrophosphate had no effect on TEER. Our immunocytochemical and Western blot analyses revealed that treatment with pitavastatin enhanced the expression of [...]
|
 1 2 3 4 5 6 7 8 
|
|
