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Results for geranylgeranyl pyrophosphate: Pubmed ( 916 ) | Free Full Text ( 143 ) | U.S. Grants ( 28 )

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Simvastatin ameliorates rat cerebrovascular remodeling during hypertension via inhibition of volume-regulated chloride channel.

Hypertension 2010,Sep,01;56(3):445-52; (PMID: 20644009)
[...]posttranslational modification of several proteins, such as Rho by mevalonate-derived isoprene groups, geranylgeranyl pyrophosphate or farnesyl pyrophosphate, underlie the pleiotropic effects of statins, the detailed mechanisms remain elusive.[...]

Diterpene production in Mycobacterium tuberculosis.

FEBS J 2010,Sep,01;277(17):3588-95; (PMID: 20670276)
[...] with highest abundance in Mtb has a mass fragmentation pattern identical to edaxadiene, which is produced in vitro from geranylgeranyl diphosphate by the enzymes Rv3377c and Rv3378c. A second diterpene found in Mtb has a similar mass spectrum, and is always observed in the same proportion relative to edaxadiene, indicating that it is a side product of the Rv3378c reaction in vivo.[...]

Lovastatin inhibits EGFR dimerization and AKT activation in squamous cell carcinoma cells: potential regulation by targeting rho proteins.

Oncogene 2010,Aug,19;29(33):4682-92; (PMID: 20562912)
[...]The effects of lovastatin on EGFR function were reversed by the addition of geranylgeranyl pyrophosphate, which functions as a protein membrane anchor. Lovastatin treatment induced actin cytoskeletal disorganization and the expression of geranylgeranylated rho family proteins that regulate the actin [...]

Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control.

Proc Natl Acad Sci U S A 2010,Aug,03;107(31):13654-9; (PMID: 20643967) [FULL TEXT AVAILABLE]
[...]dimethylallyl diphosphate precursors and reprogrammed the rate-limiting downstream pathway by generating combinatorial mutations in geranylgeranyl diphosphate synthase and levopimaradiene synthase. The mutant library contained pathway variants that not only increased diterpenoid production but also tuned the selectivity toward [...]

Isoprenoids, small GTPases and Alzheimer's disease.

Biochim Biophys Acta 2010,Aug,01;1801(8):896-905; (PMID: 20382260)
[...]Isoprenoids are a complex class of biologically active lipids including for example, dolichol, ubiquinone, farnesylpyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP). Early work had shown that the long-chain isoprenoid dolichol is decreased but that [...]

Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo.

Cardiovasc Res 2010,Jul,15;87(2):385-93; (PMID: 20045866)
[...]METHODS AND RESULTS: The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin suppressed basal and cytokine-treated EL expression in endothelial cells. Concomitant treatment with mevalonate or geranylgeranyl pyrophosphate completely reversed the inhibitory effect of pitavastatin, suggesting that geranylgeranylated proteins are involved in the [...]

17-Hydroxygeranyllinalool glycosides are major resistance traits of Nicotiana obtusifolia against attack from tobacco hornworm larvae.

Phytochemistry 2010,Jul,01;71(10):1115-21; (PMID: 20452633)
[...]To evaluate the defensive value of these HGL-DTGs, we used virus-induced-gene silencing to reduce the transcript levels of geranylgeranyl diphosphate synthase and total HGL-DTG levels in both species. When fed on silenced plants, larvae gained up to about two times more mass than those that fed on empty vector control plants of both species.[...]

The inhibition of mevalonate pathway induces upregulation of NALP3 expression: new insight in the pathogenesis of mevalonate kinase deficiency.

Eur J Hum Genet 2010,Jul,01;18(7):844-7; (PMID: 20179743)
[...], and nonsterol-isoprenoids biosynthesis. The shortage of mevalonate-derived intermediates, and in particular of geranylgeranyl pyrophosphate (GGPP), has been linked with the activation of caspase-1 and thereby with the production of IL-1beta, but the true concatenation of these two events has not been clarified yet.[...]

Cloning and functional analysis of the second geranylgeranyl diphosphate synthase gene influencing helvolic acid biosynthesis in Metarhizium anisopliae.

Appl Microbiol Biotechnol 2010,Jul,01;87(3):1077-88; (PMID: 20393706)
A gene (ggs2) having high similarity to the geranylgeranyl diphosphate synthase (GGPP synthase) gene was cloned from Metarhizium anisopliae NAFF635007. The ggs2 gene (1,239-bp open reading frame with no intron) encoded a protein of 412 amino acids, and the [...]

Pitavastatin strengthens the barrier integrity in primary cultures of rat brain endothelial cells.

Cell Mol Neurobiol 2010,Jul,01;30(5):727-35; (PMID: 20127168)
[...]The increase in TEER was significantly reduced in the presence of isoprenoid geranylgeranyl pyrophosphate, whereas farnesyl pyrophosphate had no effect on TEER. Our immunocytochemical and Western blot analyses revealed that treatment with pitavastatin enhanced the expression of [...]
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