novoseek report on 2010-09-08
MEDLINE
Search : BRCA1
Filter(s) : brca2 mutation, Comment
Excluding filter(s) :
Date restrictions :
Items 1 - 10 of 37

Evaluating women with ovarian cancer for BRCA1 and BRCA2 mutations: missed opportunities.

Obstet Gynecol 2010,Aug,01;116(2 Pt 1):440-1; author reply 441; (PMID: 20664408)
Herman, Jonathan;

Weighing options for cancer risk reduction in carriers of BRCA1 and BRCA2 mutations.

J Clin Oncol 2010,Jan,10;28(2):189-91; (PMID: 19996025)
Stadler, Zsofia K ; Kauff, Noah D;

One-hit effects and cancer.

Cancer Prev Res (Phila Pa) 2010,Jan,01;3(1):12-5; (PMID: 20051368)
Iniesta, Maria D ; Chien, Janet ; ... ; Merajver, Sofia D ;
[...]This perspective on Bellacosa et al. (beginning on p. 48 in this issue of the journal) discusses the important biology of microscopically normal tissues in carriers of germ-line BRCA1 or BRCA2 mutations. The work of Bellacosa et al. is an important step toward discerning which pathways[...]

Contralateral breast cancer in BRCA1/BRCA2 mutation carriers: the story of the other side.

J Clin Oncol 2009,Dec,10;27(35):5862-4; (PMID: 19858367)
Garber, Judy E ; Golshan, Mehra;

Recontacting patients who have tested negative for BRCA1 and BRCA2 mutations: how, who and why?

J Genet Couns 2009,Dec,01;18(6):527-9; (PMID: 19760496)
Hampel, Heather;

PARP inhibitors and the treatment of breast cancer: beyond BRCA1/2?

Breast Cancer Res 2009,Jan,01;11(6):111; (PMID: 20017885)
Frizzell, Kristine M ; Kraus, W Lee;
[...]) inhibitors have been explored as therapeutic agents for the treatment of hereditary breast and ovarian cancers harboring mutations in BRCA1 or BRCA2. In a new study, Inbar-Rozensal and colleagues show that phenanthridine-derived PARP inhibitors promote [...]cell cycle arrest and cell death in breast cancer cells lacking BRCA1 and BRCA2 mutations and prevent the growth of tumors from xenografts of these cells in immunocompromised mice.[...]

Towards more effective and equitable genetic testing for BRCA1 and BRCA2 mutation carriers.

J Med Genet 2008,Nov,01;45(11):765-6; (PMID: 18978334)
James, P A ; Harris, M ; ... ; Mitchell, G ;

Towards more effective and equitable genetic testing for BRCA1 and BRCA2 mutation carriers.

J Med Genet 2008,Jul,01;45(7):409-10; (PMID: 18456714)
Hopper, John L ; Dowty, James G ; ... ; Winship, Ingrid ;

Prophylactic salpingo-oophorectomy in a series of 89 women carrying a BRCA1 or a BRCA2 mutation.

Cancer 2007,Dec,15;110(12):2819; author reply 2819-20; (PMID: 17969078)
Mahajan, Niraj N;

Prognosis of breast cancer in carriers of BRCA1 and BRCA2 mutations.

N Engl J Med 2007,Oct,11;357(15):1555; author reply 1556; (PMID: 17928608)
Goodwin, Pamela J ; Phillips, Kelly-Anne ; ... ; West, Dee W ;
Related biomedical concepts
Diseases or Syndromes
brca2 mutation
breast cancer
sporadic breast cancer
atypical medullary carcinoma
ovarian cancer
contralateral breast cancer
invasive lobular carcinoma
tubular adenocarcinoma
carcinomatosis
brca1 mutation
familial cancer
lobular carcinoma
adenocarcinoma mucinous
invasive ductal carcinoma
ductal carcinoma
cancer
Genes and Proteins
BRCA2
BRCA1
PARP
Chemical substances
Poly(ADPribose)
Organisms
Mus sp
Homo sapiens
Organs and Body parts
breast
ovarian
medullary
Biological functions
pleomorphism
cell cycle arrest
cell death
linkage
pathways
Procedures and Techniques
mastectomies
genetic testing
risk reduction
ovariectomies
xenograft
Related bibliographical concepts
Author
Eisinger, F
Foulkes, William D
Birnbaum, D
Jacquemier, J
Sobol, H
Weber, Barbara L
Hopper, John L
Mitchell, G
Iniesta, Maria D
Bonadona, Valerie
Dowty, James G
Miller, L A
Goodwin, Pamela J
Nogues, C
Charafe-Jauffret, E
Ghadirian, P
Phillips, K A
DeMichele, Angela
Kauff, Noah D
Phillips, Kelly-Anne
Journal
Journal of the National Cancer Institute
JAMA : the journal of the American Medical Association
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Journal of medical genetics
Cancer
The New England journal of medicine
Gynecologic oncology
Lancet
Obstetrics and gynecology
Journal of genetic counseling
Epidemiology (Cambridge, Mass.)
Breast cancer research : BCR
ANZ journal of surgery
The lancet oncology
Cancer prevention research (Philadelphia, Pa.)
Publication type
Comment
Letter
Editorial
Journal Article
Research Support, Non-U.S. Gov't
Review
Research Support, U.S. Gov't, P.H.S.
Comparative Study
Research Support, N.I.H., Extramural