Your new biomedical search engine
try: asthma , trastuzumab , BRCA1 		Advanced Search
Preferences
Search in:
Show highlight panel
About novo|seek

Free biomedical search engine that allows you to find literature in Medline, US Grants and Full Text. Explore the results in an easy way, narrow and identify relevant results quickly.

Search examples & demo videos
Sign up for my novo|seek

Discover my novo|seek

Key concepts


Click here for more info about 'Chlorhexidine'
Chlorhexidine
Click here for more info about 'ISOPROPANOL'
ISOPROPANOL
Click here for more info about 'Influenza A'
Influenza A
Click here for more info about 'tissue culture'
tissue culture
Click here for more info about 'Antiviral'
Antiviral
more
Print

Efficacy of soap and water and alcohol-based hand-rub preparations against live H1N1 influenza virus on the hands of human volunteers.

Clin Infect Dis 2009,Feb,01;48(3):285-91; (PMID: 19115974)
Publication Type: Journal Article, Research Support, Non-U.S. Gov't
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Infectious Diseases Department, Austin Health, Heidelberg, Victoria 3084, Australia. Lindsay.Grayson@austin.org.au
article abstract
BACKGROUND: Although pandemic and avian influenza are known to be transmitted via human hands, there are minimal data regarding the effectiveness of routine hand hygiene (HH) protocols against pandemic and avian influenza. METHODS: Twenty vaccinated, antibody-positive health care workers had their hands contaminated with 1 mL of 10(7) tissue culture infectious dose (TCID)(50)/0.1 mL live human influenza A virus (H1N1; A/New Caledonia/20/99) before undertaking 1 of 5 HH protocols (no HH [control], soap and water hand washing [SW], or use of 1 of 3 alcohol-based hand rubs [61.5% ethanol gel, 70% ethanol plus 0.5% chlorhexidine solution, or 70% isopropanol plus 0.5% chlorhexidine solution]). H1N1 concentrations were assessed before and after each intervention by viral culture and real-time reverse-transcriptase polymerase chain reaction (PCR). The natural viability of H1N1 on hands for >60 min without HH was also assessed. RESULTS: There was an immediate reduction in culture-detectable and PCR-detectable H1N1 after brief cutaneous air drying--14 of 20 health care workers had H1N1 detected by means of culture (mean reduction, 10(3-4) TCID(50)/0.1 mL), whereas 6 of 20 had no viable H1N1 recovered; all 20 health care workers had similar changes in PCR test results. Marked antiviral efficacy was noted for all 4 HH protocols, on the basis of culture results (14 of 14 had no culturable H1N1; (P< .002) and PCR results (P< .001; cycle threshold value range, 33.3-39.4), with SW statistically superior (P< .001) to all 3 alcohol-based hand rubs, although the actual difference was only 1-100 virus copies/microL. There was minimal reduction in H1N1 after 60 min without HH. CONCLUSIONS: HH with SW or alcohol-based hand rub is highly effective in reducing influenza A virus on human hands, although SW is the most effective intervention. Appropriate HH may be an important public health initiative to reduce pandemic and avian influenza transmission.
Mesh Terms
Alcohols
Disinfectants
Hand
Human Experimentation
Influenza A Virus, H1N1 Subtype
more
Your search has been saved.
Your search contains date ranges. It can be saved but no alerts can be created. To create an alert please repeat the search without date ranges.
myns_savedsearch.alertcreated
Your search has been saved.
Do you want to create an email alert?

Labels will enable you to:

  • Organize your favorite papers.
  • Classify interesting documents.
  • Retrieve your labeled documents from anywhere at anytime.

To assign your labels to the documents we need you to sign-in or create an account.

Saving search results will enable you to:

  • Retrieve saved results from anywhere at anytime.
  • Set up emails alerts on your favorite searches.

To keep all this information stored we need you to sign-in or create an account.

The entity has already been added to the filters
This article will be available in PMC on .
Create Label
Name of label: